B12 Folate Supreme combines the two highly absorbable forms of B12, adenosylocobalamin and methylcobalamin with Nature Folate a blend of active folates. These vitamins work together to improve methylation and to regulate homocysteine levels in the body which improves heart health. B12 and Folate help with red blood cell formation and hence help prevent anemia. They are important to prevent birth defects. They may also reduce one’s risk of macular degeneration. Low levels of B12 have been linked to osteoporosis. B12 Folate Supreme helps improve mood and increases energy. B12 and Folate deficiency have been associated with memory loss.